Plasma p-Tau217 and Aβ42/40 for identifying amyloid PET positivity in cognitively unimpaired asian…

Meta-analysisAgeing research reviews· Jul 2026

Plasma p-Tau217 and Aβ42/40 for identifying amyloid PET positivity in cognitively unimpaired asian individuals: A systematic review and meta-analysis.

Itsuki Terao, Wakako Kodama

Neurologic ImagingMeta-analysisQ1IF 16.6

Plasma p-tau217 discriminates amyloid PET positivity well in unimpaired Asians

Plasma p-Tau217 and Aβ42/40 for identifying amyloid PET positivity in cognitively unimpaired asian individuals: A systematic review and meta-analysis.

Itsuki Terao, Wakako Kodama

Ageing research reviews · Jul 2026

Background

Blood-based biomarkers have emerged as promising tools for detecting Alzheimer disease (alzheimer disease) pathology, but their performance in cognitively unimpaired Asian populations remains unclear.

Methods

We conducted a systematic review and random-effects meta-analysis to evaluate the ability of plasma p-tau217, Aβ42/40, and composite biomarkers to discriminate amyloid-β positron emission tomography (Aβ PET) positivity in cognitively unimpaired Asian populations.

n = 2566 cognitively unimpaired

Results

AUROC for detecting amyloid PET positivity, near 1.0 means excellent discrimination

p-tau217

0.88AUC

Aβ42/40

0.86AUC

More results

In secondary analyses, the pooled SMD between Aβ PET-positive and Aβ PET-negative individuals was 2.28 for p-tau217 and -1.17 for Aβ42/40.

Composite biomarkers showed higher discriminative performance, with pooled AUCs of 0.920 for p-tau217/Aβ42 and 0.924 for combined p-tau217 and Aβ42/40 models.

“

Conclusion

In cognitively unimpaired Asian populations, plasma p-tau217 and Aβ42/40 showed good discriminative performance for Aβ PET positivity. Further standardization, external validation, and prospective evaluation are needed.

Plasma p-Tau217 and Aβ42/40 for identifying amyloid PET positivity in cognitively unimpaired asian individuals: A systematic review and meta-analysis.

Plasma p-Tau217 and Aβ42/40 for identifying amyloid PET positivity in cognitively unimpaired asian individuals: A systematic review and meta-analysis.

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