Screening for post-stroke cognitive impairment: The effect of diagnostic criteria on prevalence and false positive rates.

This study theoretically and statistically compared four statistical approaches to post-stroke cognitive impairment classification using a cognitive screen in 1,951 stroke patients and 407 healthy controls.

We contrasted (1) the common "at least one positive test" method using 5th centile cut-offs per subtest (uncorrected), (2) a Bonferroni-adjusted variant controlling for multiple comparisons, (3) a total-score summing subtest scores, and (4) a non-parametric Multivariate Normative Comparison (Multivariate Normative Comparison) approach.