Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of…

Cohort studyThyroid : official journal of the American Thyroid Association· Aug 2026

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study.

Isaline Morard, Frédéric Castinetti, Isabelle Oliver Petit … Magalie Haissaguerre

Endocrine SurgeryCohort studyTreatmentQ1IF 5.3

Permanent hypoparathyroidism followed prophylactic thyroidectomy in 16% of children with MEN2

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study.

Isaline Morard … Magalie Haissaguerre

Thyroid · Aug 2026 · Q1 in General Medicine

Background

Children carrying germline RET mutations associated with multiple endocrine neoplasia type 2 (MEN2) are at high risk of developing medullary thyroid carcinoma (medullary thyroid carcinoma).

Methods

We conducted a retrospective national multicenter cohort study within the French Groupe d'Étude des Tumeurs Endocrines, including children younger than 15 years who underwent prophylactic-intent total thyroidectomy between 2010 and 2020 in the absence of clinically apparent structural disease.

Results

permanent low parathyroid function after surgery, mostly in kids under 5

31%

Hypoparathyroidism (an

16%

Permanent hypoparathyr

More results

Sixty-four children (61 MEN2A, 3 MEN2B) underwent surgery at a median age of 4.6 years (interquartile range [IQR] = 3.2-8.3 years).

Preoperative calcitonin was elevated in 44% of evaluable patients.

Histopathology demonstrated C-cell hyperplasia in 52% and micro-medullary thyroid carcinoma in 34%, while lymph node metastases were rare (3%).

“

Conclusion · 1 of 2

In this national contemporary cohort, prophylactic-intent thyroidectomy in pediatric MEN2 was associated with excellent short-term oncologic outcomes but also with a substantial rate of permanent hypoparathyroidism, particularly in very young children.

Conclusion · 2 of 2

These findings underscore the importance of multidisciplinary evaluation of both the timing and extent of surgery in expert centers.

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study.

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study.

Related papers