Frailty combined with nutritional risk for predicting stroke-associated pneumonia: a cohort study based on a nomogram model.
Combined frailty and nutritional risk model predicted stroke-associated pneumonia far better than standard score
Frailty combined with nutritional risk for predicting stroke-associated pneumonia: a cohort study based on a nomogram model.
Stroke-associated pneumonia (stroke-associated pneumonia) is a common and serious complication in patients with acute severe stroke, and existing risk assessment tools have limited predictive accuracy in critically ill populations.
A retrospective cohort study was conducted on 293 critically ill stroke patients admitted to the Neurocritical Care Unit of the First Affiliated Hospital of Chongqing Medical University between 2013 and 2024.
model far outperformed the standard ISAN score at identifying pneumonia risk
The results of the additive interaction analysis showed a positive additive interaction between frailty and nutritional risk in the development of stroke-associated pneumonia, with an attributable proportion (attributable proportion) of 0.711 (95% CI = 0.358 ~ 1.065) and a synergy index (synergy index) of 3.694 (95% CI = 1.200 ~ 11.364).
Internal validation showed that the model achieved an accuracy of 73.93%, sensitivity of 77.30%, and specificity of 71.95%, indicating good stability.
The calibration curve demonstrated good agreement between predicted and observed outcomes.
DISCUSSION: This study is the first to integrate frailty and nutritional risk into an stroke-associated pneumonia prediction model, significantly improving early risk identification and providing an innovative, practical tool for precision prevention and targeted intervention in critically ill stroke patients.