Neuron-Specific Enolase for Neurological Prognostication After Cardiac Arrest in the Era of Targeted Temperature Management: A Systematic Review and Meta-Analysis.

Neuron-specific enolase provides good prognostic accuracy for neurological outcome prediction after cardiac arrest and remains clinically valuable in patients managed with temperature management.

Serial measurements obtained between 48 and 72 h after return of spontaneous circulation appear to provide the greatest prognostic value.

neuron-specific enolase should be interpreted as part of a multimodal neuroprognostication strategy rather than as a standalone predictor.