Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured…

Cohort studyJournal of burn care & research : official publication of the American Burn Association· Jul 2026

Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.

Hannah Kieffer, Michael D Santarelli, Anne L Wagner … Ryan J Stark

Burns & Wound ReconstructionCohort studyPrognosisQ2IF 1.8

PIICS strongly linked to recurrent infections in burn-injured adults

Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.

Hannah Kieffer … Ryan J Stark

Journal of burn care & research · Jul 2026 · Q2 in Surgery

Background

Alterations in both the innate and adaptive immune systems can induce a significant immunocompromised state among those hospitalized after burn injury.

Methods

With PIICS had more pathogens isolated and a higher prevalence of Acinetobacter and Stenotrophomonas infections.

n = 960 patients

25%

Results

25%

1 in 4 burn patients developed PIICS, tied to repeat infections

n = 960 patients

More results

The immunophenotype of PIICS was strongly associated with recurrent infections during hospitalization.

“

Conclusion

Detailed assessments of PIICS criteria, including trends in lymphocyte counts, may help identify the development of serious bacterial and fungal infections in burn-injured adults.

Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.

Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Serious Infections in Burn-Injured Adults: A Retrospective Single-Center Study from 1997 to 2023.

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