A Biomarker Coming of AGE: Skin Autofluorescence Predicts Functional Outcome after Aneurysmal Subarachnoid…

Cohort studyNeurocritical care· Aug 2026

A Biomarker Coming of AGE: Skin Autofluorescence Predicts Functional Outcome after Aneurysmal Subarachnoid Hemorrhage.

Alexandra Filipov, Martin Andermann, Silvia Schönenberger … Jessica Jesser

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Neurocritical CareCohort studyPrognosisQ1IF 3.3

Higher skin autofluorescence linked to worse 90-day outcome after brain hemorrhage

A Biomarker Coming of AGE: Skin Autofluorescence Predicts Functional Outcome after Aneurysmal Subarachnoid Hemorrhage.

Alexandra Filipov … Jessica Jesser

Neurocritical care · Aug 2026 · Q1 in Neurology

Background

Early risk stratification following aneurysmal subarachnoid hemorrhage (aSAH) is clinically challenging.

Methods

In a prospective single-center cohort study, skin autofluorescence was measured during the index hospital stay in consecutive adult patients with confirmed aSAH.

n = 50 patients

Results

OR 9.8

each unit rise in skin fluorescence nearly tenfolds the odds of poor recovery

n = 50 patients

More results

A total of 50 patients completed 90-day follow-up; 22 (44%) experienced poor functional outcome.

Discriminative performance was excellent (AUC 0.81).

An optimal skin autofluorescence cutoff value of ≥ 2.6 yielded a sensitivity of 0.82, specificity of 0.71, positive predictive value of 0.69, and negative predictive value of 0.83.

More results

Skin autofluorescence showed a moderate association with DCI (p = 0.045; AUC 0.68) but not with radiographic vasospasm (p = 0.35).

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Conclusion · 1 of 3

Bedside skin autofluorescence predicts poor 90-day functional outcome following aSAH and is associated with DCI, but not with radiographic vasospasm.

Conclusion · 2 of 3

These findings support a pathophysiological role for chronic metabolic vulnerability in determining secondary brain injury severity and functional recovery after aSAH.

Conclusion · 3 of 3

The prospective cohort is currently being expanded, and external validation in larger prospective multicenter cohorts is warranted.

A Biomarker Coming of AGE: Skin Autofluorescence Predicts Functional Outcome after Aneurysmal Subarachnoid Hemorrhage.

A Biomarker Coming of AGE: Skin Autofluorescence Predicts Functional Outcome after Aneurysmal Subarachnoid Hemorrhage.

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