Clinical characteristics and outcomes of macrolide-resistant Mycoplasma pneumoniae infection in hospitalized children: a single-center retrospective cohort study in Chengdu, China.
Fever lasting over 6.5 days strongly predicts refractory Mycoplasma pneumoniae pneumonia
Clinical characteristics and outcomes of macrolide-resistant Mycoplasma pneumoniae infection in hospitalized children: a single-center retrospective cohort study in Chengdu, China.
The rising global prevalence of macrolide-resistant Mycoplasma pneumoniae (macrolide-resistant Mycoplasma pneumoniae) poses a significant challenge in managing Mycoplasma pneumoniae pneumonia (mycoplasma pneumoniae pneumonia) in children, particularly in China.
This study aimed to characterize the clinical features and outcomes of macrolide-resistant Mycoplasma pneumoniae infection and develop a predictive model for refractory MPP progression.
Were divided into an macrolide-resistant Mycoplasma pneumoniae group (n=95) and a non-macrolide-resistant Mycoplasma pneumoniae group (n=80) based on 23S rRNA gene mutations detected in Mycoplasma pneumoniae from bronchoalveolar lavage fluid (bronchoalveolar lavage fluid).
fever over 6.5 days raises refractory mycoplasma pneumoniae pneumonia risk more than 12-fold
The prevalence of macrolide-resistant Mycoplasma pneumoniae was 54.3% (95/175), with all strains carrying the A2063G mutation.
Within the macrolide-resistant Mycoplasma pneumoniae group, refractory MPP patients were older and had more severe clinical and radiological manifestations.
A prediction model incorporating these factors achieved an area under the curve (AUC) of 0.918 (95% CI: 0.863-0.973, P<0.001).
Macrolide-resistant Mycoplasma pneumoniae infection in children is associated with more severe pulmonary and extrapulmonary manifestations and a higher risk of progressing to refractory MPP.
The developed prediction model, utilizing easily obtainable clinical parameters, demonstrates high diagnostic accuracy for early identification of refractory MPP risk, potentially facilitating timely intervention and improving patient outcomes.