Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery After Aesthetic or Reconstructive…

StudyPlastic and reconstructive surgery· Jul 2026

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery After Aesthetic or Reconstructive Procedures.

Samuel J Lin, Jessica McCoun, Daneshvari Solanki … Todd Bertoch

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Aesthetic & Cosmetic SurgeryStudyTreatmentQ1IF 2.8

Suzetrigine-based multimodal therapy allowed opioid-free recovery after cosmetic surgery in most patients

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery After Aesthetic or Reconstructive Procedures.

Samuel J Lin … Todd Bertoch

Plastic and reconstructive surgery · Jul 2026 · Q1 in Surgery

Background

Suzetrigine is a non-opioid, highly selective NaV1.8 pain-signal inhibitor of the voltage-gated sodium channel NaV1.8, with no addiction potential approved in the US for moderate-to-severe acute pain in January 2025.

Methods

Underwent aesthetic/reconstructive surgeries wherein opioids are commonly used ≥72h postoperatively.

n = 99

Results

most patients avoided opioids entirely for pain control after surgery

Suzetrigine MMT (no op

90.9%

Literature (mixed cosm

10%

More results

Patients (N=99) underwent various procedures, the most common being aesthetic and reconstructive breast procedures (33.3% and 13.1%, respectively), abdominoplasty with liposuction (28.3%), and turbinoplasty (13.1%).

More results

Most patients (90.7%) rated suzetrigine as part of MMT as good/very good/excellent on a patient global assessment for pain control at end of treatment, which was consistently high across surgeries.

Most common MMT was suzetrigine with only acetaminophen and/or ibuprofen (78.8%), while 12.1% used suzetrigine alone.

“

Conclusion

Suzetrigine demonstrated highly effective pain management and enabled opioid-free recovery for most patients (90.9%) when initiated preoperatively and as part of MMT in aesthetic and reconstructive surgeries wherein opioids are commonly used postoperatively; in contrast, in studies of mixed cosmetic procedures in the literature, <10% did not require opioids.

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery After Aesthetic or Reconstructive Procedures.

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery After Aesthetic or Reconstructive Procedures.

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