Psychiatric Comorbidities Requiring Antidepressant Therapy and Their Impact on Wound Healing and…

Cohort studyThe Journal of craniofacial surgery· May 2026

Psychiatric Comorbidities Requiring Antidepressant Therapy and Their Impact on Wound Healing and Postoperative Complications in Facial Plastic Surgery: A Propensity-Score Matched Analysis.

Aneeq S Chaudhry, William Tian, Megan M Perez … Marco F Ellis

Aesthetic & Cosmetic SurgeryCohort studyClinical practiceQ2IF 1.1

Preoperative antidepressant use linked to higher infection rates after facial plastic surgery

Psychiatric Comorbidities Requiring Antidepressant Therapy and Their Impact on Wound Healing and Postoperative Complications in Facial Plastic Surgery: A Propensity-Score Matched Analysis.

Aneeq S Chaudhry … Marco F Ellis

The Journal of craniofacial surgery · May 2026 · Q2 in Surgery

Background

Antidepressant medications are widely prescribed, yet their perioperative effects in facial plastic surgery remain poorly defined.

Purpose

This study evaluated the association between preoperative antidepressant exposure and postoperative complications following aesthetic facial plastic surgery procedures.

Methods

Undergoing rhinoplasty, blepharoplasty, or rhytidectomy were identified using procedural codes.

n = 18,064 patients

Results

antidepressant users had higher odds of postoperative infection

RR by subgroup · 95% CI

More results

Infection was the most consistent signal across all follow-up intervals.

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Conclusion · 1 of 2

Preoperative antidepressant exposure was associated with increased postoperative morbidity following aesthetic facial plastic surgery.

Conclusion · 2 of 2

These findings highlight the importance of incorporating antidepressant use into perioperative risk assessment and patient counseling.

Psychiatric Comorbidities Requiring Antidepressant Therapy and Their Impact on Wound Healing and Postoperative Complications in Facial Plastic Surgery: A Propensity-Score Matched Analysis.

Psychiatric Comorbidities Requiring Antidepressant Therapy and Their Impact on Wound Healing and Postoperative Complications in Facial Plastic Surgery: A Propensity-Score Matched Analysis.

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