Impact of Perioperative Opioid Prescriptions on Early and Late Complications After Rhinoplasty: A…

Cohort studyThe Journal of craniofacial surgery· Jun 2026

Impact of Perioperative Opioid Prescriptions on Early and Late Complications After Rhinoplasty: A Propensity-Matched Study.

Aneeq S Chaudhry, Anshumi Desai, Sinan K Jabori … Devinder P Singh

Aesthetic & Cosmetic SurgeryCohort studyQ2IF 1.1

Perioperative opioids linked to more than double the overall complication rate after rhinoplasty

Impact of Perioperative Opioid Prescriptions on Early and Late Complications After Rhinoplasty: A Propensity-Matched Study.

Aneeq S Chaudhry … Devinder P Singh

The Journal of craniofacial surgery · Jun 2026 · Q2 in Surgery

Background

Rhinoplasty is one of the most commonly performed facial plastic surgery procedures.

Purpose

This study aims to evaluate the association between perioperative opioid prescriptions and postoperative complications following rhinoplasty procedures.

Methods

Were stratified by documented opioid prescriptions within 2 weeks postoperatively.

n = 107,396 controls

Results

opioid use more than doubled early overall complication risk after rhinoplasty

RR 2.11 (95% CI 1.94 to 2.29)

CI excludes the null - significant

More results

A total of 419,449 rhinoplasty patients were identified, including 312,053 with perioperative opioid exposure and 107,396 controls.

After propensity score matching, 85,201 patients remained in each cohort.

More results

During late follow-up, opioid exposure remained associated with higher rates of surgical site complications (RR 1.14, P=0.0049), infection (RR 1.48, P=0.0003), and wound disruption (RR 1.36, P=0.0044).

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Conclusion

Perioperative opioid prescriptions were associated with increased postoperative complications following rhinoplasty. These findings support continued efforts to optimize opioid-sparing analgesic strategies in rhinoplasty-related procedures.

Impact of Perioperative Opioid Prescriptions on Early and Late Complications After Rhinoplasty: A Propensity-Matched Study.

Impact of Perioperative Opioid Prescriptions on Early and Late Complications After Rhinoplasty: A Propensity-Matched Study.

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