Some good news in a changing world? Is the incidence of pyloric stenosis decreasing?
Breastfeeding was associated with lower risk of pyloric stenosis than formula feeding
Some good news in a changing world? Is the incidence of pyloric stenosis decreasing?
Infantile hypertrophic pyloric stenosis (infantile hypertrophic pyloric stenosis) is a common cause of gastric outlet obstruction in infancy, but its incidence in the Australian Capital Territory (Australian Capital Territory) region has not been previously studied.
This study aimed to analyse changes in infantile hypertrophic pyloric stenosis incidence over thirty years and evaluate potential factors related to infantile hypertrophic pyloric stenosis, including antibiotic use, proton pump inhibitor (pump inhibitor) use, and feeding methods.
We retrospectively analysed the clinical records of infantile hypertrophic pyloric stenosis patients from 1992 to 2022.
There were 154,026 registered births in the Australian Capital Territory region from 1992 to 2022.
A total of 327 cases of infantile hypertrophic pyloric stenosis were identified, with an overall incidence rate of 2.12 per 1000 live births.
Although there were some fluctuations, the incidence rate showed a decreasing trend overall, from 3.16 per 1000 live births in 1992 to 0.94 per 1000 live births in 2022.
Pump inhibitor use was associated with a significant increase in risk (approximately 400%) (p = 0.032) compared to infants without pump inhibitor exposure.
Our data indicate a trend of decreasing infantile hypertrophic pyloric stenosis incidence rates from 1992 to 2022.
The results suggest that breastfeeding reduces the risk of developing infantile hypertrophic pyloric stenosis, while pump inhibitor use is associated with the later development of infantile hypertrophic pyloric stenosis.
LEVEL OF EVIDENCE: Level 3. TYPE OF STUDY: Retrospective case control study.