Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort…

ObservationalBritish journal of clinical pharmacology· Aug 2026

Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients.

Emilie Laval, Sylvain Goutelle, Inesse Boussaha … Behrouz Kassai

Pediatric Hospital MedicineObservationalQ1IF 2.9

4.3% of hospitalized children had at least one contraindicated drug-drug interaction.

Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients.

Emilie Laval … Behrouz Kassai

British journal of clinical pharmacology · Aug 2026

Background

Drug-drug interactions (drug-drug interactions) are associated with an increased risk of adverse drug reactions (adverse drug reactions).

Purpose

The aims of this study were to characterize contraindicated drug-drug interactions detected in paediatric hospital wards and to assess whether these interactions were associated with adverse drug reactions.

Methods

Aged ≤15 years, hospitalized for >3 days and receiving at least two medication during their stay were eligible.

n = 4543 hospitalized children

Results

about 1 in 23 hospitalized children had a contraindicated drug interaction

12.5%

Any DDI

4.3%

Contraindicated DDI

More results

Overall, 4225 drug-drug interactions were identified, including 709 classified as contraindicated.

Thus 72% of the contraindicated drug-drug interactions occurred in three departments: paediatric cardiology, developmental psychopathology ward and pulmonology/allergology/cystic fibrosis.

More results

Most contraindicated drug-drug interactions (80%) were observed in children aged 2-11 years and 12-15 years.

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Conclusion · 1 of 2

Although a large number of drug-drug interactions were detected in hospitalized paediatric patients, contraindicated drug-drug interactions were rarely associated with clinically relevant adverse drug reactions.

Conclusion · 2 of 2

These findings highlight the need to improve the specificity and clinical relevance of drug-drug interactions alert systems in paediatric inpatient settings.

Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients.

Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients.

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