Programming of deep brain stimulation of the centromedian nucleus of the thalamus for drug-resistant epilepsy: A meta-analysis and proposed programming framework.

Thirty studies including 269 individuals met inclusion criteria.

Generalized tonic-clonic seizures were associated with greater seizure reduction.

Tonic seizures were associated with worse outcome, yet this was attenuated after accounting for study clustering.

No single nominal stimulation parameter demonstrated a robust clinically actionable association with outcome; however, estimated total electrical energy delivered was associated with greater seizure reduction on multivariable modeling, yet this was attenuated when accounting for clustering between studies.