Impact of vancomycin administration modality on target attainment in acutely ill children-a propensity score…

Cohort studyEuropean journal of pediatrics· Aug 2026

Impact of vancomycin administration modality on target attainment in acutely ill children-a propensity score matching analysis.

Dominik Armatys, Anaïs Briant, Pascal Thibon … Isabelle Goyer

Pediatric Critical & Emergency CareCohort studyTreatmentQ1IF 3.2

Continuous infusion vancomycin linked to higher early target attainment than intermittent dosing in children.

Impact of vancomycin administration modality on target attainment in acutely ill children-a propensity score matching analysis.

Dominik Armatys … Isabelle Goyer

European journal of pediatrics · Aug 2026 · Q1 in Pediatrics

Background

UNLABELLED: Vancomycin is widely used in children, yet achieving therapeutic targets is challenging.

Purpose

This study compared first-line strategies of vancomycin CI and intermittent dosing (II) in acutely ill hospitalized children.

Methods

Were allocated to CI or II based on vancomycin administration modality.

50%

Results

50%

vs 23%

continuous infusion more than doubled early target attainment vs intermittent dosing

More results

This is a retrospective single-center study with propensity score matching (propensity score matching) and inverse probability of treatment weighting (IPWT) including pediatric inpatients (0-17 years) receiving intravenous vancomycin between January 2022 and May 2024 with at least one plasma level measured.

More results

CI patients were younger and more frequently hospitalized in intensive care settings.

Time to target attainment was shorter with CI (median 2 vs 3 days).

Adverse events were rare and comparable between groups.

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Conclusion · 1 of 3

Vancomycin CI as a first-line strategy instead of classic II in acutely ill children seems promising for efficient target attainment without an increase in adverse events.

Conclusion · 2 of 3

Prospective multicenter studies are needed to confirm optimal dosing regimens.

Conclusion · 3 of 3

WHAT IS KNOWN: • Achieving therapeutic vancomycin exposure in children is difficult due to high pharmacokinetic variability, and intermittent infusion frequently fails to reach recommended AUC-based targets.

Impact of vancomycin administration modality on target attainment in acutely ill children-a propensity score matching analysis.

Impact of vancomycin administration modality on target attainment in acutely ill children-a propensity score matching analysis.

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