Postoperative Seizure Prophylaxis in Intracranial Tumors: Evaluating the Role of Anti-Seizure Medication in Seizure-Naïve Patients.

Postoperative seizure risk varies by tumor type, cortical involvement, peritumoral edema, hemorrhage, and tumor grade.

When prophylaxis is employed, second-generation anti-seizure medications such as levetiracetam are often favored for their higher tolerability and fewer drug-drug interactions compared to older agents.

Emerging evidence has described alternative agents to levetiracetam with greater blood-brain-barrier permeability, but further investigation is required.

A selective, risk-based approach with short-term prophylaxis may be considered in patients with high-risk features.