Rapid Genome Sequencing Identifies Treatable Conditions in Non-Intensive Care Unit Hospitalized Children.

Eighty-one percent of non-intensive care unit diagnostic rapid genome sequencing had a management change within 30 days, and 56% (18/32) received a disease- targeted intervention including medication or diet change, listing for transplant, or connection with a clinical trial.

Of the children who received these intervention changes, the most common disease categories were metabolic (61%, 11/18) and epilepsy (22%, 4/18).