Assessment of Adverse Events Using the Therapy-Disability-Neurology (TDN) Grading System in a Cohort of…

Cohort studyBrain sciences· May 2026

Assessment of Adverse Events Using the Therapy-Disability-Neurology (TDN) Grading System in a Cohort of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Center Retrospective Cohort Study.

Vincens Kälin, Alexis Paul Romain Terrapon, Anna Maria Zeitlberger … Isabel Charlotte Hostettler

CerebrovascularCohort studyPrognosisQ2IF 3.6

Therapy-Disability-Neurology grade correlates with functional outcome after aneurysmal subarachnoid hemorrhage

Assessment of Adverse Events Using the Therapy-Disability-Neurology (TDN) Grading System in a Cohort of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Center Retrospective Cohort Study.

Vincens Kälin … Isabel Charlotte Hostettler

Brain sciences · May 2026

Background

Adverse events (adverse events) associated with neurosurgical interventions can cause neurological deficits and impaired functional outcomes.

Purpose

We aimed to validate the Therapy-Disability-Neurology grade in predicting functional outcomes and length of hospital stay (LOS) in aSAH patients, treated surgically and/or endovascularly.

Methods

Were recruited between 2009 and 2022.

n = 355 patients

rho = -0.58

Results

rho = -0.58

worse long-term functional outcomes track with higher Therapy-Disability-Neurology grade

n = 355 patients

More results

We included 355 patients: mean age was 57.2 (12.9 SD) and 235 (66.1%) were female.

The Therapy-Disability-Neurology grade showed a moderate positive correlation with length of hospital stay (rho = 0.4, p < 0.001).

More results

The Therapy-Disability-Neurology grade demonstrated good discrimination for unfavorable outcome at last follow-up (AUC = 0.82) and good discrimination for employment status (AUC = 0.71).

Patients with AEs stayed 7.63 days longer on average ( p < 0.001).

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Conclusion · 1 of 3

The Therapy-Disability-Neurology grade predicted hospital stay and functional outcomes in aSAH patients treated surgically and/or endovascularly, demonstrating good discrimination for unfavorable outcomes and employment status.

Conclusion · 2 of 3

These findings extend the grade's applicability to both treatment- and disease-related complications and support its potential utility as a standardized tool for prognostication and resource planning.

Conclusion · 3 of 3

Results should be interpreted in light of the single-center retrospective design and selection bias.

Assessment of Adverse Events Using the Therapy-Disability-Neurology (TDN) Grading System in a Cohort of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Center Retrospective Cohort Study.

Assessment of Adverse Events Using the Therapy-Disability-Neurology (TDN) Grading System in a Cohort of Aneurysmal Subarachnoid Hemorrhage Patients: A Single-Center Retrospective Cohort Study.

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