Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A…

Cohort studyDiagnostics (Basel, Switzerland)· Jul 2026

Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A Descriptive Single-Centre Observational Study.

Alina Mariela Murgu, Adriana Mihai, Paula Popovici … Codrina Ancuța

Pediatric RheumatologyCohort studyQ2IF 4.4

Autoimmune thyroiditis was the most common comorbidity in juvenile idiopathic arthritis with autoimmune disease

Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A Descriptive Single-Centre Observational Study.

Alina Mariela Murgu … Codrina Ancuța

Diagnostics (Basel, Switzerland) · Jul 2026 · Q2 in General Medicine

Background

Children with juvenile idiopathic arthritis (juvenile idiopathic arthritis) frequently develop additional autoimmune conditions during follow-up, yet the clinical and diagnostic profile of this comorbid subgroup is incompletely characterised in single-centre paediatric series.

Purpose

We aimed to describe the prevalence, clinical pattern, and diagnostic features of autoimmune comorbidities in a seven-year cohort of children with juvenile idiopathic arthritis monitored at a single tertiary paediatric centre, and to document the diagnostic protocols applied for each comorbidity.

Methods

We conducted a retrospective descriptive observational study of 103 consecutive children with juvenile idiopathic arthritis classified according to the ILAR 2001 criteria and monitored at the Paediatric Rheumatology Unit of St.

n = 103 children

47.6%

Results

47.6%

nearly half of juvenile idiopathic arthritis patients with autoimmune disease had thyroiditis

n = 103 children

More results

Autoimmune comorbidity was identified in 21 of 103 children (20.4%; 95% confidence interval [CI] 13.1-29.5%), the JIA-AID subgroup.

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Conclusion · 1 of 2

Autoimmune comorbidity affected approximately one in five children with juvenile idiopathic arthritis in this single-centre cohort, with autoimmune thyroiditis and inflammatory bowel disease as the most frequent associations and a notable concentration of comorbidity within the HLA-B27-positive enthesitis-related arthritis subtype.

Conclusion · 2 of 2

These descriptive observations are hypothesis-generating and support the case for proactive multidisciplinary screening in selected subgroups.

Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A Descriptive Single-Centre Observational Study.

Clinical Profile and Diagnostic Spectrum of Autoimmune Comorbidities in Juvenile Idiopathic Arthritis: A Descriptive Single-Centre Observational Study.

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