Closing the evidence gap: Capillary high-sensitivity troponin I verification in an African population using…

Cross-sectionalClinica chimica acta; international journal of clinical chemistry· Aug 2026

Closing the evidence gap: Capillary high-sensitivity troponin I verification in an African population using point of care.

Maseti Amvuyele Ann, Jacob Doreen, Khoza Siyabonga, Chikomba Chemedzai

Acute Chest Pain & TroponinCross-sectionalQ1IF 4.1

Capillary point-of-care troponin agreed with lab serum at 99th-percentile diagnostic threshold

Closing the evidence gap: Capillary high-sensitivity troponin I verification in an African population using point of care.

Maseti Amvuyele Ann … Chikomba Chemedzai

Clinica chimica acta; international journal of clinical chemistry · Aug 2026 · Q1 in General Medicine

Background

High sensitivity cardiac troponin I (hs-cTnI) assays are central to the early diagnosis and rule-out of acute myocardial infarction (acute myocardial infarction).

Purpose

This study evaluated the performance of capillary hs-cTnI point-of-care sampling in an African population.

Methods

This cross-sectional method comparison study evaluated paired capillary hs-cTnI measurements obtained on point-of-care against corresponding venous serum and plasma samples analysed on a central laboratory assay.

n = 110 patients

92.1%

Results

92.1%

capillary readings matched lab-confirmed heart attack diagnosis in most patients

n = 110 patients

More results

Capillary hs-cTnI showed moderate correlation with both plasma (r s = 0.788; 95% CI 0.694-0.855) and serum (r s = 0.791; 95% CI 0.699-0.857).

Mean bias of capillary versus plasma was -15.9% (-173% to +143%) and - 12.9% (-171% to +145%) compared with serum.

Serum comparison met the predefined allowable minimum bias of 13.6%.

More results

No significant asymmetry in discordant classifications was observed (p = 0.7266; 95% CI -8.27 to 3.88).

“

Conclusion

Capillary whole-blood hs-cTnI testing demonstrated acceptable analytical agreement and high clinical concordance with central laboratory measurement, supporting its implementation to enhance rapid acute myocardial infarction assessment in resource-limited emergency settings.

Closing the evidence gap: Capillary high-sensitivity troponin I verification in an African population using point of care.

Closing the evidence gap: Capillary high-sensitivity troponin I verification in an African population using point of care.

Related papers