Phenotypes of atopic dermatitis and long-term body mass index trajectories.
Late-onset atopic dermatitis in boys linked to lower-increasing BMI trajectory
Phenotypes of atopic dermatitis and long-term body mass index trajectories.
Evidence linking atopic dermatitis (atopic dermatitis) to obesity is inconsistent, partly because prior studies overlooked the disease's clinical heterogeneity.
This study aimed to identify longitudinal atopic dermatitis and body mass index (BMI) trajectories from childhood to adolescence and examine their concurrent associations.
Data from 20,158 children in a Japanese nationwide birth cohort followed for 13 years were analyzed.
boys with late-onset atopic dermatitis were more likely to shift toward a lower-then-rising BMI path
In girls, "Late-onset" atopic dermatitis was associated with the "Low-Increasing" (aOR, 1.88; 1.35-2.64) and "High-Decreasing" (aOR, 1.45; 1.06-1.98) BMI; early-onset phenotypes showed no significant associations.
The longitudinal clinical course of childhood atopic dermatitis is concurrently associated with distinct, sex-specific BMI trajectories, highlighting a parallel relationship between cutaneous symptom development and somatic growth.
IMPACT: Longitudinal phenotypes of childhood atopic dermatitis (atopic dermatitis) are associated with distinct, sex-specific body mass index (BMI) trajectories.
Using a 13-year nationwide birth cohort, we show a parallel relationship between the atopic dermatitis course and somatic growth.