The dynamics of cerebral blood flow and cerebral oedema evaluated by MRI following resuscitation from cardiac arrest; a porcine study.

Indications of cytotoxic oedema were present at 6 hours in the form of lower apparent diffusion coefficient in the cardiac arrest group in the left cortex with a mean difference of 57.8 10 -6 mm 2 /s (95% CI: 12.8 - 102.8; p=.006) and in the right cortex with a mean difference of 64.4 10 -6 mm 2 /s (95% CI: 21.3 - 107.5; p=.001).

Neuronal damage was evident by higher neuron specific enolase at 24 hours in the cardiac arrest group with a mean difference of -1.14 μg/L (95% CI: -1.77 - -0.50; p<.001).