Diagnostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in pediatric syncope in the emergency department: a prospective study.

Cardiac etiology was identified in 8.6% of patients, while vasovagal, idiopathic, neurologic, orthostatic, and psychogenic syncope accounted for 27.9%, 28.9%, 15.2%, 5.6%, and 7.6% of cases, respectively.

The median serum NT-proBNP levels were 437.4 ng/L, 44.5 ng/L, and 37.1 ng/L in children with cardiac syncope, non-cardiac syncope, and healthy children (p < 0.001, p = 0.008, and p = 0.971, respectively).

Serum NT-proBNP levels have been shown to be a promising biomarker for predicting cardiac syncope in children.