INFRAPATELLAR FAT PAD MRI RADIOMICS AND DELTA-RADIOMICS FOR PREDICTING PAIN PROGRESSION IN KNEE OSTEOARTHTRITIS.
Infrapatellar fat pad delta-radiomics over two years strongly predicted knee osteoarthritis pain progression.
INFRAPATELLAR FAT PAD MRI RADIOMICS AND DELTA-RADIOMICS FOR PREDICTING PAIN PROGRESSION IN KNEE OSTEOARTHTRITIS.
Knee osteoarthritis (knee osteoarthritis) pain is often discordant with structural abnormalities on conventional imaging, limiting the ability of routine magnetic resonance imaging (magnetic resonance imaging) to predict symptom progression.
To determine whether baseline infrapatellar fat pad magnetic resonance imaging radiomics and two-year infrapatellar fat pad delta-radiomics can predict pain progression in knee osteoarthritis and whether their performance exceeds that of clinical features and whole-joint magnetic resonance imaging Osteoarthritis Knee Score (MRI Osteoarthritis Knee Score) models.
We conducted a retrospective cohort study using 1,822 knee magnetic resonance imaging scans from the Osteoarthritis Initiative.
The baseline infrapatellar fat pad radiomics model showed stable predictive performance, with AUCs of 0.731 in internal validation and 0.732 in the external test set.
This exceeded the performance of clinical-feature models (AUC 0.534-0.587) and MRI Osteoarthritis Knee Score-based models (AUC 0.532-0.586).
In multivariable regression, the infrapatellar fat pad radiomics score remained an independent predictor of knee osteoarthritis pain progression.
Quantitative magnetic resonance imaging radiomics of the infrapatellar fat pad may provide a robust imaging biomarker for predicting knee osteoarthritis pain progression.
Incorporating infrapatellar fat pad radiomics, particularly longitudinal delta-radiomics, may improve risk stratification beyond clinical features and conventional semi-quantitative magnetic resonance imaging assessment.