An indocyanine green-potentiated gastrin releasing peptide receptor-targeting multifunctional peptide-drug conjugate for prostate cancer therapy.

Here, we present PXC-4, a Gastrin Releasing Peptide Receptor (Gastrin Releasing Peptide Receptor)-targeting multifunctional peptide-drug conjugates based on Gastrin Releasing Peptide Receptor antagonist JMV-594 and the cytotoxic payload monomethyl auristatin E (monomethyl auristatin E), for precise prostate cancer therapy.

PXC-4, by leveraging indocyanine green (indocyanine green) and radionuclide ( 64 Cu/ 177 Lu), acquired multifunctionality and optimized antitumor activity.

Upon 808 nm laser irradiation, PXC-4 further achieved 99% tumor suppression through photodynamic therapy coupled with its cytotoxic payload.