Diagnostic impact of tau versus amyloid PET in patients with cognitive symptoms.

They underwent comprehensive clinical assessment, amyloid positron emission tomography, and tau positron emission tomography.

For Alzheimer's disease (AD) diagnosis, tau positron emission tomography demonstrated high sensitivity (97.8%) and specificity (95.4%), showing substantial agreement with amyloid positron emission tomography.

In patients clinically diagnosed with non-AD disorders, tau positron emission tomography led to a significantly higher rate of diagnostic change compared with amyloid positron emission tomography (p = 0.018).