Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion…

StudyNuclear medicine communications· Jul 2026

Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion studies as marker of stress adequacy by semiquantitative analysis of acquired single-photon emission computed tomography/computed tomography images.

Noor F AlKandari, Maryam M Bouzabar, Danah A AlDhafiri … Issa Loutfi

Cardiovascular ImagingStudyDiagnosisQ3IF 1.4

Spleen-to-vertebra uptake ratio falls significantly with adenosine stress, confirming splenic switch-off.

Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion studies as marker of stress adequacy by semiquantitative analysis of acquired single-photon emission computed tomography/computed tomography images.

Noor F AlKandari … Issa Loutfi

Nuclear medicine communications · Jul 2026 · Q3 in Radiology

Purpose

Adenosine pharmacological stress is commonly used for the detection of ischemia by myocardial perfusion imaging (myocardial perfusion imaging) using radiotracers and gated single-photon emission computed tomography/computed tomography (SPECT/CT) imaging.

Methods

Seventeen adenosine myocardial perfusion imaging studies were selected.

Results

Spleen/vertebra ratio during stress was lower than at rest, indicating adequate adenosine effect.

0.98ratio

S/V Adenosine

1.87ratio

S/V Rest

More results

Mean age was 60.35 years, with 9 males (53%).

The mean M/VAd was 2.86 ± 1.65 and M/VRst 3.75 ± 2.41 (t = -1.323, P = 0.204).

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Conclusion

Using the method outlined, especially the S/V ratio, evaluation of the splenic switch-off can be achieved from the acquired data, which shows promise as a marker for adequate effectiveness of adenosine stress in doubtful cases.

Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion studies as marker of stress adequacy by semiquantitative analysis of acquired single-photon emission computed tomography/computed tomography images.

Evaluation of adenosine-induced splenic switch-off in Tc-99m tetrofosmin (Myoview) myocardial perfusion studies as marker of stress adequacy by semiquantitative analysis of acquired single-photon emission computed tomography/computed tomography images.

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