Quantitative CZT SPECT Myocardial Blood Flow for Physiological Assessment and Risk Stratification of Cardiac…

Cohort studyCirculation. Cardiovascular imaging· Jul 2026

Quantitative CZT SPECT Myocardial Blood Flow for Physiological Assessment and Risk Stratification of Cardiac Allograft Vasculopathy.

Paul Hart, Anas Jawaid, Jeffrey Fitch … Ronald G Schwartz

Cardiovascular ImagingCohort studyDiagnosisQ1IF 3.6

Stress myocardial blood flow is lower in advanced cardiac allograft vasculopathy

Quantitative CZT SPECT Myocardial Blood Flow for Physiological Assessment and Risk Stratification of Cardiac Allograft Vasculopathy.

Paul Hart … Ronald G Schwartz

Circulation · Jul 2026 · Q1 in Radiology

Background

Cardiac allograft vasculopathy (cardiac allograft vasculopathy) remains a major cause of morbidity and mortality after orthotopic heart transplantation.

Methods

We retrospectively studied 110 consecutive orthotopic heart transplantation recipients who underwent coronary angiography and cadmium-zinc-telluride single-photon emission computed tomography quantitative myocardial blood flow imaging within 12 months.

n = 110 consecutive orthotopic heart

1.25

Results

1.25

vs 2.03 mL/min per g

stress blood flow drops as vasculopathy worsens

n = 110 consecutive orthotopic heart

More results

The Bravo and Hart algorithms showed similar discrimination of advanced cardiac allograft vasculopathy by paired DeLong comparison (area under the curve, 0.773 versus 0.717; Δ area under the curve, 0.056; P =0.606).

Severely reduced coronary flow capacity was associated with higher event rates (28.6% versus 5.2%; P =0.015).

More results

The Hart framework demonstrated exploratory prognostic separation (35.3% versus 3.2%; P =0.001).

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Conclusion · 1 of 2

Quantitative cadmium-zinc-telluride single-photon emission computed tomography-derived myocardial blood flow and coronary flow capacity provide physiological assessment and risk stratification of cardiac allograft vasculopathy, with preliminary associations with cardiac allograft vasculopathy-related events.

Conclusion · 2 of 2

These findings support the prospective multicenter evaluation of cadmium-zinc-telluride single-photon emission computed tomography myocardial blood flow as a widely available, noninvasive orthotopic heart transplantation surveillance strategy.

Quantitative CZT SPECT Myocardial Blood Flow for Physiological Assessment and Risk Stratification of Cardiac Allograft Vasculopathy.

Quantitative CZT SPECT Myocardial Blood Flow for Physiological Assessment and Risk Stratification of Cardiac Allograft Vasculopathy.

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