Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [ 177 Lu]Lu-PSMA SPECT/CT Imaging…

StudyJournal of nuclear medicine : official publication, Society of Nuclear Medicine· Jul 2026

Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [ 177 Lu]Lu-PSMA SPECT/CT Imaging with Comparisons to [ 68 Ga]Ga-PSMA PET.

Caroline Boursier, Sébastien Heyer, Abdelaali Zouaoui … Laetitia Imbert

Oncologic ImagingStudyClinical practiceQ1IF 6.5

9-minute dual-energy SPECT protocol measures 15% lower tumor volume than 18-minute scan.

Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [ 177 Lu]Lu-PSMA SPECT/CT Imaging with Comparisons to [ 68 Ga]Ga-PSMA PET.

Caroline Boursier … Laetitia Imbert

Journal of nuclear medicine · Jul 2026 · Q1 in Radiology

Background

Eighteen-minute 360° cadmium zinc telluride (cadmium zinc telluride) total-body 177 Lu-labeled SPECT acquisitions on the single 113-keV 177 Lu photopeak (SP-18) have been reported to be suitable for monitoring [ 177 Lu]Lu-PSMA therapy.

Purpose

This study evaluated dual-energy 113- and 208-keV acquisitions with a more than 2-fold increase in acquired counts, allowing acquisition time to be reduced to 9 min (DP-9).

Methods

In 20 patients with prostate cancer, 360° cadmium zinc telluride total-body 177 Lu-labeled SPECT acquisitions performed after the first [ 177 Lu]Lu-PSMA therapeutic injection were reconstructed as SP-18, DP-9, and dual-energy 18-min reconstructions (DP-18), all from the same list-mode dataset, and tumor volume and SUV mean were compared.

n = 20 patients

-15%

Results

-15%

the faster scan reads tumors smaller, closer to PET truth than the standard scan

n = 20 patients

More results

DP-9 yielded tumor volume and SUV mean that were comparable to those of DP-18.

Phantom results were similar for SPECT reconstructions, with PET showing better recovery coefficients for SUV and volume.

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Conclusion · 1 of 2

Dual-energy 360° cadmium zinc telluride total-body [ 177 Lu]Lu-PSMA SPECT/CT enables 9-min acquisitions while providing tumor volume and SUV mean measurements comparable to those of the previously validated 18-min single-energy protocol.

Conclusion · 2 of 2

Tumor volumes are lower than those with SP-18 but are closer to PET-derived values. Differences between SPECT and PET mainly reflect the injection-to-imaging time for SUV mean and the spatial resolution for tumor volume.

Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [ 177 Lu]Lu-PSMA SPECT/CT Imaging with Comparisons to [ 68 Ga]Ga-PSMA PET.

Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [ 177 Lu]Lu-PSMA SPECT/CT Imaging with Comparisons to [ 68 Ga]Ga-PSMA PET.

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