Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study.

Cohort studyEndocrine pathology· Jul 2026

Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study.

Vania Balderrama-Brondani, Leonardo Marcal, Mohammad Jad Moussa … Mouhammed Amir Habra

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Molecular Genetic PathologyCohort studyPrognosisQ1IF 3.6

Detected circulating tumor DNA strongly associated with active disease in adrenocortical carcinoma.

Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study.

Vania Balderrama-Brondani … Mouhammed Amir Habra

Endocrine pathology · Jul 2026 · Q1 in General Medicine

Background

Adrenocortical carcinoma (adrenocortical carcinoma) is a rare malignancy with high recurrence rates.

Methods

This retrospective, single-institution, study evaluated real-world use of ctDNA testing in patients with adrenocortical carcinoma and its correlation with imaging-based tumor burden.

Results

ctDNA detected means disease is active, far more often than not

OR 74 (95% CI 9 to 3438)

null 1

9

3438

CI excludes the null - significant

More results

Circulating tumor DNA (ctDNA) is a minimally invasive, blood-based biomarker with multiple oncologic applications.

The median ctDNA level was 1.27 mean tumor molecules/mL (IQR, 0.05-22.86).

More results

The ctDNA assay demonstrated high sensitivity (88%), specificity (91.7%), and overall accuracy (88.5%), with a positive post-test probability of 98% and a negative post-test probability of 45%.

In addition, ctDNA levels were positively correlated with tumor burden (Spearman R = 0.844; p < 0.001).

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Conclusion

These findings support the potential value of ctDNA testing for disease monitoring in adrenocortical carcinoma and it may support a more personalized approach to this rare disease.

Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study.

Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study.

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