A novel approach to radioembolization treatment planning using a hybrid [ 99m Tc]Tc-MAA contrast enhanced…

Cohort studyEuropean journal of nuclear medicine and molecular imaging· Jul 2026

A novel approach to radioembolization treatment planning using a hybrid [ 99m Tc]Tc-MAA contrast enhanced SPECT/CT.

Grace Keane, Marnix G E H Lam, Maarten L J Smits … Arthur J A T Braat

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TheranosticsCohort studyClinical practiceQ1IF 5.8

Hybrid SPECT/ceCT planning yielded 6% higher index tumor radiation doses than conventional planning.

A novel approach to radioembolization treatment planning using a hybrid [ 99m Tc]Tc-MAA contrast enhanced SPECT/CT.

Grace Keane … Arthur J A T Braat

European journal of nuclear medicine and molecular imaging · Jul 2026 · Q1 in Radiology

Purpose

This study evaluates a hybrid SPECT/ceCT-based planning methodology, hypothesising that it yields significantly different dosimetry metrics compared to the conventional workflow.

Methods

Hybrid SPECT/ceCT was performed in 24 patients with hepatocellular carcinoma.

n = 24 patients

6%

Results

6%

hybrid planning delivered higher radiation doses to the tumor itself

n = 24 patients

More results

Index lesion volume increase between baseline ceCT and SPECT/ceCT was 14% (95% LoA: -55.9%, 82.9%).

Index lesion dose (p = 0.01) and volume (p = 0.01) differed significantly between workflows.

More results

The median deviation of the index lesion between the baseline diagnostic image and hybrid SPECT/ceCT image was 4.9 ± 2.2 mm and there was an average DICE score of 0.6 ± 0.2.

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Conclusion

Hybrid [99mTc]Tc-MAA SPECT/ceCT treatment planning is technically feasible and leads to significant differences in dosimetry metrics compared with the conventional method.

A novel approach to radioembolization treatment planning using a hybrid [ 99m Tc]Tc-MAA contrast enhanced SPECT/CT.

A novel approach to radioembolization treatment planning using a hybrid [ 99m Tc]Tc-MAA contrast enhanced SPECT/CT.

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