Evaluation of sleep, fatigue, and quality of life in patients with primary immunodeficiency.
Poor sleep quality is strongly linked to more severe fatigue in primary immunodeficiency
Evaluation of sleep, fatigue, and quality of life in patients with primary immunodeficiency.
Primary immunodeficiency (primary immunodeficiency) is a heterogeneous group of genetic disorders characterized by recurrent infections and immune dysregulation.
This study aimed to evaluate sleep quality, fatigue, and health-related quality of life in adults with primary immunodeficiency and to explore the associations between comorbidities and treatment modalities.
This retrospective, observational, single-center study was conducted at the University of Health Sciences, Gülhane Training and Research Hospital between May and August 2024.
Patients with autoimmune and inflammatory bowel disease had significantly worse Pittsburgh Sleep Quality Index and Fatigue Severity Scale scores, whereas bronchiectasis was associated with reduced SF-36 physical scores.
No differences were observed between the IVIG and SCIG groups in fatigue or mental scores; however, SCIG recipients had significantly higher physical scores (P = 0.018).
Patients with primary immunodeficiency experience substantial impairment in physical quality of life, with fatigue and poor sleep quality frequently coexisting.
Comorbidities, such as autoimmunity, bronchiectasis, and inflammatory bowel disease, exacerbate these impairments. SCIG therapy confers better physical outcomes than IVIG therapy.
Comprehensive care strategies that address psychosocial and physical health are essential for the management of primary immunodeficiency.