Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French…

Cohort studyThe Journal of infectious diseases· Jun 2026

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

Deborah To Puzenat, Morgane Cheminant, Eric Dannaoui … Cléa Melenotte

Allergy & ImmunologyCohort studyPrognosisQ1IF 3.8

Cryptosporidiosis was fatal in over 40% of patients with inborn errors of immunity.

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

Deborah To Puzenat … Cléa Melenotte

The Journal of infectious diseases · Jun 2026 · Q1 in Immunology & Allergy

Background

Inborn Errors of Immunity (Inborn Errors of Immunity) display increased susceptibility to infections among which cryptosporidiosis is an opportunistic infection poorly characterized in this population.

Methods

Diagnosed with an Inborn Errors of Immunity between 1986 and 2025 and who experienced proven cryptosporidiosis were included.

n = 10,004 patients

Results

17 of 41 patients with cryptosporidiosis died in this registry cohort.

Cholangitis

50%

HSCT indication

63%

HSCT performed

38%

Died

41.5%

More results

Of the 10,004 patients in the CEREDIH registry, 149 were identified with at least one episode of parasitic infection (≈1.4%).

The male-to-female ratio was 1.92 and the mean age at onset of cryptosporidiosis was 16.6±17.5 years.

“

Conclusion · 1 of 2

Cryptosporidiosis is a serious comorbidity in patients with Inborn Errors of Immunity with a high mortality rate reaching more than one third of the patients.

Conclusion · 2 of 2

CID including Hyper IgM syndrome and other CID were the most represented underlying condition in this study with the highest morbidity and mortality (cholangitis and its complications).

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

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