A high FIB-4 score may be an early sign of severe liver involvement in patients with primary antibody deficiencies.

FIB-4 scores were significantly higher in common variable immunodeficiency patients than in those with SGD (p = 0.003), and were also elevated in primary antibody deficiencies patients with hematology and gastroenterology/hepatology phenotypes compared with rheumatology + dermatology and respiratory phenotypes (p < 0.001).

FIB-4 and elastography showed moderate to good agreement (κ = 0.41-0.60) for detecting significant fibrosis, and FIB-4 was also a valuable indicator in high-risk patients (≥3.25).