Efficacy and safety of nasal saline irrigation for allergic rhinitis in children and adolescents: A systematic review and meta-analysis with GRADE assessment.

Nasal saline irrigation is an effective and safe intervention for children and adolescents with allergic rhinitis, offering clinically meaningful improvements in nasal symptoms and a significant medication-sparing effect.

nasal saline irrigation can reasonably be considered as an adjunctive therapy alongside standard pharmacological care, with the choice of saline tonicity potentially tailored to the predominant symptom phenotype, although the predominance of high risk-of-bias evidence warrants confirmation in more rigorous trials.