Plasma Metabolomic and Proteomic Profiling of the Mechanisms Underlying the Cumulative Impact of Co-occurring Psychiatric Disorders on Atopic Dermatitis.

High-definition likelihood and bidirectional GSMR assessed shared genetic architecture and directionality.

Genetic liability to 5 psychiatric traits was associated with higher atopic dermatitis risk, whereas reverse atopic dermatitis-to-psychiatric effects were not supported.

Psychiatric disorders were prospectively associated with incident atopic dermatitis, with higher risk among participants with co-occurring disorders and higher weighted psychiatric burden.

Proteomic analyses prioritized HLA-DRA, MMP12, TNFRSF14, and VCAM1 as nonspecific inflammatory proteins associated with atopic dermatitis risk in psychiatric populations.