Congenital Ichthyosis is Associated with Increased Risk of Allergic Disorders.

Overall, 115 of 130 invited subjects completed surveys.

Significantly higher rates of allergic rhinitis, food allergy, and allergic asthma were found in congenital ichthyosis, compared to age-matched population data.

Highest rates were in erythrodermic types (Netherton syndrome, ichthyosis with confetti, and harlequin ichthyosis), consistent with their higher barrier impairment, but also in X-linked ichthyosis (similar barrier impairment to atopic dermatitis).