Sex differences in acute chest pain care in a multisite U.S. emergency department cohort.

ObservationalThe American journal of emergency medicine· Jul 2026

Sex differences in acute chest pain care in a multisite U.S. emergency department cohort.

Kyle H McKnight, Anna C Snavely, Lyle Paukner … Simon A Mahler

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Emergency MedicineObservationalQ1IF 2.1

Women with chest pain had lower odds of death or myocardial infarction than men.

Sex differences in acute chest pain care in a multisite U.S. emergency department cohort.

Kyle H McKnight … Simon A Mahler

The American journal of emergency medicine · Jul 2026 · Q1 in Emergency Medicine

Background

Large studies examining sex-based differences in emergency department (emergency department) cardiovascular care are lacking.

Purpose

This analysis compared cardiovascular healthcare utilization and safety outcomes between women and men in a large U.

Methods

We conducted an observational study of emergency department patients ≥18 years old presenting with chest pain from 1/2021-12/2021 across 25 EDs.

n = 40,979 patients

Results

women had lower odds of death or heart attack than men

AOR by subgroup · 95% CI

More results

Among 40,979 patients, 56.6% (23,188/40,979) were female with mean age 52.

Death or myocardial infarction at 30 days occurred in 2.4% (552/23,188) of women and 5.2% (917/17,791) of men (p < 0.001).

Hospitalizations occurred in 30.2% (6998/23,188) of women compared to 36.0% (6411/17,791) of men (p < 0.001).

More results

OCT occurred in 14.9% (3452/23,188) of women and 19.6% (3488/17,791) of men (p < 0.001).

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Conclusion

In a large emergency department cohort of patients with chest pain, rates of death or myocardial infarction, hospitalizations, and OCT at 30-days were lower in women compared to men.

Sex differences in acute chest pain care in a multisite U.S. emergency department cohort.

Sex differences in acute chest pain care in a multisite U.S. emergency department cohort.

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