Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month…

Cohort studyBMC cardiovascular disorders· Jun 2026

Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month mortality after PCI: insights from a prospective large-scale registry.

Xueqing Yang, Kun Na, Miaohan Qiu … Yaling Han

Acute Chest Pain & TroponinCohort studyPrognosisQ2IF 3.1

Elevated troponin after percutaneous coronary intervention linked to higher mortality in women than men

Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month mortality after PCI: insights from a prospective large-scale registry.

Xueqing Yang … Yaling Han

BMC cardiovascular disorders · Jun 2026

Background

Post-procedural high-sensitivity cardiac troponin T (hs-TnT) is an established prognostic marker in patients with acute coronary syndrome (acute coronary syndrome) undergoing percutaneous coronary intervention (percutaneous coronary intervention).

Purpose

This study aimed to investigate whether the association between elevated hs-TnT and clinical outcomes differs by sex, and to characterize sex-specific dose-response relationships.

Methods

Were stratified by post-procedural hs-TnT concentrations measured within 48 h after percutaneous coronary intervention (< 0.5 vs. ≥ 0.5 ng/mL).

n = 14,214 patients

Results

elevated troponin raised death risk far more in women than men

AHR by subgroup · 95% CI

More results

For cardiac death, similar differences were observed (P for interaction = 0.023).

Restricted cubic spline analysis revealed a nonlinear relationship between hs-TnT and mortality in females (P for nonlinearity = 0.01), whereas the relationship was linear in males (P for nonlinearity = 0.12).

More results

The formal test of interaction between continuous hs-TnT and sex confirmed this divergence (P = 0.0042).

“

Conclusion · 1 of 2

The prognostic impact of elevated post-procedural hs-TnT on mortality was substantially greater in female than in male acute coronary syndrome patients.

Conclusion · 2 of 2

These hypothesis-generating findings suggest that sex-specific approaches to troponin-based risk stratification after percutaneous coronary intervention warrant further investigation.

Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month mortality after PCI: insights from a prospective large-scale registry.

Sex-specific non-linear association between post-procedural high-sensitivity troponin t and 12-month mortality after PCI: insights from a prospective large-scale registry.

Related papers