The Prevalence of Contact Allergy to Formaldehyde and Formaldehyde Releasers: A Systematic Review and Meta-Analysis.

The pooled prevalence for releasers was 2.76% for 2-bromo-2-nitropropane-1,3-diol, 1.89% for quaternium-15, 1.42% for diazolidinyl urea, 1.37% for DMDM hydantoin, and 1.20% for imidazolidinyl urea.

Significant sensitization rates were observed in different geographic regions, with the highest prevalence found in North America (6.8%).

The prevalence rate was 2.96% among children and 2.61% among adults, with no significant difference.

The prevalence rate was 2.65% among patients with atopic dermatitis (atopic dermatitis) and 2.85% among patients without atopic dermatitis, with no significant difference.