A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among…

Cohort studyFrontiers in medicine· 2026

A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among candidates for Biologic Therapy.

Michela Pozza, Gabriella Guarnieri, Andrea Vianello

Cardiopulmonary RehabilitationCohort studyQ1IF 3.4

Nearly one in four severe asthma patients qualify for pulmonary rehabilitation referral

A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among candidates for Biologic Therapy.

Michela Pozza … Andrea Vianello

Frontiers in medicine · 2026 · Q1 in General Medicine

Background

Despite optimized pharmacological therapy, a significant subset of severe asthma patients remains poorly controlled.

Purpose

To characterize clinical, functional, and inflammatory profile of severe asthma patients at the time of prescribing biologic therapy and identify potential candidates to ARM (ARM) pulmonary rehabilitation (pulmonary rehabilitation) program.

Methods

This retrospective study analyzed 195 consecutive adults meeting GINA criteria for severe asthma admitted to our outpatient clinic between January 1, 2015, and December 31, 2025.

n = 47 patients

24%

Results

24%

nearly 1 in 4 severe asthma patients would benefit from pulmonary rehab referral

n = 47 patients

More results

The median age of the cohort was 55 years and 60% of patients were female.

A substantial disease burden was detected (median ACT: 16; annual exacerbations: 3).

“

Conclusion · 1 of 2

At the time of biologic prescription, a significant proportion of severe asthma patients present a multidimensional burden, including dyspnea, frequent exacerbations, and psychological comorbidities and are potential candidates to Assessment-Rehabilitate-Maintenance pulmonary rehabilitation program.

Conclusion · 2 of 2

Prospective studies are needed to validate patient selection criteria and support whether pulmonary rehabilitation-may improve clinical and functional outcomes in target subgroup.

A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among candidates for Biologic Therapy.

A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among candidates for Biologic Therapy.

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