Validation of a 0/2-Hour Point-Of-Care High Sensitivity Troponin Algorithm: A Multisite US Study. | ScholarDeck

Paper

Validation of a 0/2-Hour Point-Of-Care High Sensitivity Troponin Algorithm: A Multisite US Study.

New research · Emergency Medicine

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 3w

Cohort studyAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine· Jul 2026

Validation of a 0/2-Hour Point-Of-Care High Sensitivity Troponin Algorithm: A Multisite US Study.

Simon A Mahler, Nicklaus P Ashburn, Akalya Villenthi … Anna C Snavely

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Acute Chest Pain & TroponinCohort studyDiagnosisQ1IF 2.0

Point-of-care troponin algorithm ruled out myocardial infarction with 99.4% negative predictive value

Validation of a 0/2-Hour Point-Of-Care High Sensitivity Troponin Algorithm: A Multisite US Study.

Simon A Mahler … Anna C Snavely

Academic emergency medicine · Jul 2026 · Q1 in Emergency Medicine

Purpose

The objective of this study was to validate and optimize the performance of the 0/2-h algorithm in a multisite U.

Methods

A prospective cohort study was conducted at three U.

n = 578 patients

99.4%

Results

99.4%

a negative result almost always means no heart attack

n = 578 patients

More results

These patients were 48% (279/578) female, 40% (233/578) non-White, with a median age of 60 years (IQR: 50-70).

Index myocardial infarction occurred in 7.4% (43/578).

The rule-in zone was associated with a PPV of 62.7% (95% CI: 48.1%-75.9%).

More results

Among 36.3% (210/578) patients classified to the observation zone, 4.3% (9/210) had an adjudicated index myocardial infarction.

“

Conclusion

The original Australian and optimized 0/2-h algorithms for i-STAT point-of-care hs-cTnI measurement had high NPV and efficacy in a multisite U. S.

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