Association of troponin-defined myocardial injury with adverse long-term survival among patients with chronic kidney disease.
Troponin-defined myocardial injury associated with higher long-term mortality in chronic kidney disease patients
Association of troponin-defined myocardial injury with adverse long-term survival among patients with chronic kidney disease.
Chronic kidney disease (chronic kidney disease) is associated with increased mortality, however, the impact of troponin-defined myocardial injury within this population remains poorly understood.
This study aimed to investigate the associations between troponin-defined myocardial injury and long-term mortality in chronic kidney disease patients.
This observational study analyzed 22,772,953 weighted records of adult chronic kidney disease patients from National Health and Nutrition Examination Survey (1999-2004) databases.
myocardial injury raised long-term death risk 81%
Patients with troponin-defined myocardial injury were older and had a higher prevalence of cardiovascular disease, hypertension, diabetes, as well as a lower estimated glomerular filtration rate (eGFR), compared with those without troponin-defined myocardial injury.
Sensitivity analysis excluding records with pre-existing cardiovascular disease showed similar trends, with an aHR of 1.86 (95% CI 1.56-2.21) for all-cause mortality and 2.44 (95% CI 1.83-3.24) for cardiovascular mortality.
As a marker for troponin-defined myocardial injury, hs-cTns were independently associated with worse long-term survival among chronic kidney disease patients.
However, the observational design precludes causal inference, and single time-point troponin measurements limit the assessment of dynamic changes in myocardial injury.