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Paper

Analysis of eight OTC drug components in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry.

New research · Emergency Medicine

Legal medicine (Tokyo, Japan) · 3w

Case reportLegal medicine (Tokyo, Japan)· Aug 2026

Analysis of eight OTC drug components in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry.

Tadashi Nishio, Yoko Toukairin, Tomoaki Hoshi … Makoto Nogami

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Toxicology & PoisoningCase reportQ2IF 1.6

Dried blood spot LC-MS/MS method precisely quantifies eight over-the-counter drugs

Analysis of eight OTC drug components in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry.

Tadashi Nishio … Makoto Nogami

Legal medicine (Tokyo, Japan) · Aug 2026

Background

Recently, abuse and fatal overdoses of over-the-counter (OTC) medications have become serious social and health issues worldwide.

Results

13.0%

under 13% variation between runs, results stay consistent and reliable

More results

The linearities of the calibration curves were good in the concentration range of 0.1-2.0 μg/mL.

Comparison with our general practice method showed good positive correlations at the quantifiable concentrations of all drugs.

“

Conclusion

Comparison with our general practice method showed good positive correlations at the quantifiable concentrations of all drugs.

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