Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in…

StudyPediatric radiology· Jun 2026

Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in adolescents: a non-inferiority study compared with the two-dimensional gold standard.

Wei Chen, Shuo Liu, Wei Li … Lei Xu

RadiologyStudyDiagnosisQ1IF 2.2

3D ultrafast cardiac MRI scan time is far shorter than standard 2D protocol in adolescents

Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in adolescents: a non-inferiority study compared with the two-dimensional gold standard.

Wei Chen … Lei Xu

Pediatric radiology · Jun 2026 · Q1 in Radiology

Background

Cardiac magnetic resonance (cardiac magnetic resonance) is the gold standard for assessing cardiac anatomy and function.

Purpose

To perform a non-inferiority analysis comparing a novel 3-dimensional (D) ultrafast cardiac magnetic resonance protocol against the conventional 2-dimensional (D) gold standard for evaluating cardiac function, strain, and tissue characterization in adolescents.

Methods

Thirty-nine adolescents (mean age 12.2±2.6 years) underwent both a standard 2-D protocol and a 3-D ultrafast protocol at 3-T.

n = 39

Results

3D scan takes under 2 minutes, versus over 12 for standard 2D

75.8s

3-D protocol

734.4s

2-D protocol

More results

Image quality scores were comparable between protocols (median score 4.0, P=0.74).

The 3-D protocol demonstrated statistical non-inferiority for all functional and strain metrics.

More results

Bland-Altman analysis showed minimal bias for key parameters, and the 95% confidence intervals for differences met the pre-specified non-inferiority margins.

Intraclass correlation coefficients (intraclass correlation coefficients) indicated good to excellent agreement for all parameters (n=39).

“

Conclusion · 1 of 2

The novel 3-D ultrafast cardiac magnetic resonance protocol is non-inferior to the conventional 2-D gold standard for quantitative assessment of cardiac function and strain in adolescents.

Conclusion · 2 of 2

It offers comparable image quality with significantly reduced acquisition times, potentially improving clinical feasibility in pediatric populations.

Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in adolescents: a non-inferiority study compared with the two-dimensional gold standard.

Validation of a novel three-dimensional ultrafast cardiac magnetic resonance imaging protocol in adolescents: a non-inferiority study compared with the two-dimensional gold standard.

Related papers