Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI.

Cohort studyAnnals of the American Thoracic Society· Aug 2026

Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI.

Janice J Chung, Eugene Oh, Michelle J Lee … Daniel M Beswick

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Rhinology & SinusCohort studyTreatmentQ1IF 3.2

Sinus opacification decreased substantially in young children with cystic fibrosis after ETI therapy

Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI.

Janice J Chung … Daniel M Beswick

Annals of the American Thoracic Society · Aug 2026

Purpose

Evaluate if early therapeutic initiation may begin ameliorating olfactory dysfunction in addition to chronic rhinosinusitis in young children with cystic fibrosis.

Methods

Participants ≤ 10 years were enrolled across six U.

n = 31 participants

25.5%

Results

25.5%

sinuses cleared substantially, opacification dropped a quarter

n = 31 participants

More results

31 participants (mean age 4.8 years) enrolled, 27 initiated treatment, and 26 completed follow-up (mean treatment duration 1.0 years).

More results

Following therapy, three olfactory measures improved: odor identification scores increased by 1.3 points (p = 0.03), olfactory bulb volume increased by 7.4mm3 (p = 0.02), and olfactory cleft opacification decreased by 14.4% (p = 0.004).

Quality of life scores remained at near-normal levels.

“

Conclusion · 1 of 2

Children receiving therapy demonstrated improvements in olfactory function, olfactory structure, and sinonasal opacification.

Conclusion · 2 of 2

Predominantly stable, near-normal quality of life metrics preliminarily suggest symptom-based instruments alone may be insufficient to identify sinonasal disease and treatment response at this age.

Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI.

Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI.

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