Socioeconomic and regional influences on eosinophilic inflammation in chronic rhinosinusitis with nasal polyps.
Blood eosinophil counts weakly correlate with tissue eosinophils in chronic rhinosinusitis with nasal polyps
Socioeconomic and regional influences on eosinophilic inflammation in chronic rhinosinusitis with nasal polyps.
Eosinophilic inflammation is a key feature of chronic rhinosinusitis with nasal polyps (chronic rhinosinusitis with nasal polyps); however, the extent to which peripheral blood eosinophil counts reflect local nasal eosinophilia remains controversial, particularly across different geographic regions and socioeconomic contexts.
We conducted a multicenter retrospective study involving 1047 patients with chronic rhinosinusitis with nasal polyps who underwent endoscopic sinus surgery at 3 tertiary hospitals in Jiangsu Province, China.
Linear regression analysis revealed a modest overall association between peripheral blood and nasal mucosa eosinophil counts (adjusted R 2 = 0.053).
Linear mixed-effects models confirmed heterogeneous temporal trends in both blood and tissue eosinophil counts across hospitals ( P < 0.01).
Additionally, city-level analyses revealed positive correlations between mean peripheral blood eosinophil counts and total gross domestic product (ρ = 0.80, P = 0.014) and between nasal mucosa eosinophil counts and gross domestic product per capita (ρ = 0.72, P = 0.037).
Peripheral blood eosinophil count is a poor surrogate for local tissue inflammation in chronic rhinosinusitis with nasal polyps.
Substantial regional, temporal, and socioeconomic heterogeneity underscores the need to consider geographic context when interpreting eosinophil-based biomarkers in clinical assessment and disease stratification.