Hypofractionated Versus Conventional Postmastectomy Radiotherapy in Implant-Based Breast Reconstruction: A…

Cohort studyJournal of clinical medicine· Jul 2026

Hypofractionated Versus Conventional Postmastectomy Radiotherapy in Implant-Based Breast Reconstruction: A Systematic Review and Meta-Analysis.

Ji Hyeon Joo, Yongkan Ki, Youn-Joo Jung … Su Bong Nam

Breast ReconstructionCohort studyTreatmentQ2IF 3.5

Hypofractionated radiotherapy is associated with lower capsular contracture risk after implant reconstruction

Hypofractionated Versus Conventional Postmastectomy Radiotherapy in Implant-Based Breast Reconstruction: A Systematic Review and Meta-Analysis.

Ji Hyeon Joo … Su Bong Nam

Journal of clinical medicine · Jul 2026 · Q2 in General Medicine

Background

The safety of hypofractionated postmastectomy radiotherapy (hypofractionated postmastectomy radiotherapy) in patients undergoing implant-based breast reconstruction remains uncertain because of concerns regarding radiation-related reconstructive complications.

Methods

PubMed, Cochrane Library, and EMBASE databases were searched through August 2025 following PRISMA guidelines.

n = 2200 patients

Results

hypofractionated radiotherapy lowers capsular contracture risk versus standard fractionation

OR by subgroup · 95% CI

More results

Implant or tissue expander removal (OR 0.90, 95% CI 0.67-1.22) or infection (OR 0.98, 95% CI 0.67-1.44) did not differ.

In subgroup analyses, reduction in capsular contracture was most evident when PMRT was delivered during the tissue expansion phase.

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Conclusion

These findings suggest that moderate hypofractionation is a reasonable fractionation option for implant-based breast reconstruction, with no evidence of increased reconstructive complications, although the certainty of evidence was limited, and prospective validation is warranted.

Hypofractionated Versus Conventional Postmastectomy Radiotherapy in Implant-Based Breast Reconstruction: A Systematic Review and Meta-Analysis.

Hypofractionated Versus Conventional Postmastectomy Radiotherapy in Implant-Based Breast Reconstruction: A Systematic Review and Meta-Analysis.

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