Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and…

ReviewJournal of medical imaging and radiation oncology· Aug 2026

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis.

Bader Aloufi, Roger Fulton, Kathy Willowson, Peter L Kench

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Nuclear & Molecular ImagingReviewDiagnosisQ2IF 1.3

DynSPECT liver function score correlates strongly with Hepaplastin blood test results.

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis.

Bader Aloufi … Peter L Kench

Journal of medical imaging and radiation oncology · Aug 2026 · Q2 in Radiology

Background

Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging modality that enables estimation of temporal changes in radiopharmaceutical distribution and physiological function.

Purpose

This review aims to investigate the role and effectiveness of dynSPECT in assessing hepatic function.

Methods

Following PRISMA guidelines, literature searches were conducted in MEDLINE, PubMed, Scopus, Embase, IEEE, and Web of Science, including all publications available up to December 2025 that assessed liver function using dynSPECT imaging, standard laboratory function tests and clinical scoring systems.

n = 715 participants

Results

higher scores track higher Hepaplastin levels, indicating better liver function

r 0.55 (95% CI 0.45 to 0.64)

null 0

0.45

0.64

CI excludes the null - significant

More results

Furthermore, the comparison between the two dynSPECT parameters and clinical scoring systems, including the Child-Pugh score, MELD, and the histologic activity index (histologic activity index), has a significant effect on liver disease assessment, with a combined p-value < 0.001.

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Conclusion

DynSPECT is a useful tool for the assessment of liver function in patients with hepatic dysfunction, providing results comparable to clinical laboratory function tests and scoring systems.

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis.

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis.

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