A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung…

Cohort studyDigestive diseases and sciences· Jul 2026

A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung Transplant Recipients.

Yasseen El Abdellaoui, Daniel Dong, Julia Zweifach … Isabel Neuringer

Abdominal & Body ImagingCohort studyPrognosisQ2IF 2.1

Pancreatic cysts found in over 40% of cystic fibrosis lung transplant recipients.

A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung Transplant Recipients.

Yasseen El Abdellaoui … Isabel Neuringer

Digestive diseases and sciences · Jul 2026

Background

Individuals with cystic fibrosis (cystic fibrosis) develop pancreatic cysts and cancer more frequently than the general population, particularly among lung transplant recipients due to long-term immunosuppression.

Purpose

We aim to highlight the increased risk that cystic fibrosis lung transplant patients face for developing pancreatic cysts and malignancy.

Methods

An observational, retrospective chart review of cystic fibrosis lung transplant recipients (N = 54) was conducted monitoring pancreatic cyst incidence and severity.

n = 30 patients

40.7%

Results

40.7%

over 40% developed pancreatic cysts, far above the general population

n = 30 patients

More results

Nearly, all patients underwent post-transplant, abdominal CT (100%), and ultrasound (98.1%), while 30 patients (55.6%) received an MRI/MRCP.

Of those with cysts, 7 (31.8%) had cysts detected pre-transplant, while 15 (68.2%) had cysts detected post-transplant.

Seven patients (31.8%) were diagnosed with suspected IPMNs.

More results

Seven patients (31.8%) had cysts measuring ≥ 30 mm, 4 (18.2%) exhibited main pancreatic duct dilation > 5 mm, and 8 patients (36.4%) showed a cystic growth rate ≥ 3.0 mm per year.

“

Conclusion

Findings indicate a higher-than-expected pancreatic cyst and cancer prevalence, supporting the need for formal screening guidelines for cystic fibrosis lung transplant recipients.

A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung Transplant Recipients.

A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung Transplant Recipients.

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